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KMID : 0043320230460040207
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Archives of Pharmacal Research
2023 Volume.46 No. 4 p.207 ~ p.272
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Phytochemistry and pharmacology of natural prenylated flavonoids
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Hua-Wei Lv
Qiao-Liang Wang
Meng Luo
Meng-Di Zhu
Hui-Min Liang
Wen-Jing Li
Hai Cai
Zhong-Bo Zhou
Hong Wang
Sheng-Qiang Tong
Xing?Nuo Li
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Abstract
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Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value.
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KEYWORD
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